Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression
Identifieur interne : 004E80 ( Main/Exploration ); précédent : 004E79; suivant : 004E81Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression
Auteurs : Michael Maes [Thaïlande] ; Marta Kubera [Pologne] ; Ivana Mihaylova [Bulgarie] ; Michel Geffard [France] ; Piotr Galecki [Pologne] ; Jean-Clude Leunis [Belgique] ; Michael Berk [Australie]Source :
- Journal of affective disorders [ 0165-0327 ] ; 2013.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Objective: There is evidence that major depression is characterized by oxidative and nitrosative stress (O&NS). The aim of this study is to examine IgM-mediated autoimmune responses against a variety of modified neo-epitopes formed by O&NS damage to self-epitopes in chronic depression. Methods: Serum IgM antibodies directed against conjugated oleic and azelaic acid, malondialdehyde (MDA), phosphatidyl inositol (Pi), and conjugated nitric-oxide (NO) adducts, i.e., NO-tryptophan, NO-tyrosine, NO-arginine, and NO-cysteinyl, were determined in 33 healthy controls and 74 depressed patients subdivided into 28 patients with chronic (duration > 2 year) and 46 without chronic depression. Results: Serum IgM levels against all neoepitopes were significantly higher in depressed patients than in healthy controls. Moreover, the IgM levels were significantly higher, except Pi, in chronically depressed patients than in non-chronically depressed patients. Conclusions: Depression is characterized by IgM-related autoimmune responses directed against neo-epitopes that are normally hidden from the immune system but that became immunogenic secondary to damage by O&NS. The results show that the generation of neoantigenic determinants that lead to (auto)immune responses is strongly associated with chronic depression. Discussion: The damage caused by O&NS to auto-epitopes and the consequent formation of O&NS modified neoantigenic determinants may increase the risk to develop depression and in particular chronic depression through transition to autoimmune reactions. This has implications for understanding the immuno-inlfammatory and oxidative-autoimmune pathways that lead to chronic depression and neuroprogression in that illness.
Affiliations:
- Australie, Belgique, Bulgarie, France, Pologne, Thaïlande
- Aquitaine, Aquitaine-Limousin-Poitou-Charentes, Sofia-ville (oblast)
- Bordeaux, Sofia, Talence
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000A05
- to stream PascalFrancis, to step Corpus: 000E18
- to stream PascalFrancis, to step Curation: 005471
- to stream PascalFrancis, to step Checkpoint: 000876
- to stream Main, to step Merge: 005050
- to stream Main, to step Curation: 004E80
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression</title><author><name sortKey="Maes, Michael" sort="Maes, Michael" uniqKey="Maes M" first="Michael" last="Maes">Michael Maes</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Maes Clinics @ TRIA</s1><s2>Bangkok</s2><s3>THA</s3><sZ>1 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>Maes Clinics @ TRIA</wicri:noRegion></affiliation></author><author><name sortKey="Kubera, Marta" sort="Kubera, Marta" uniqKey="Kubera M" first="Marta" last="Kubera">Marta Kubera</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Experimental Endocrinology, Institute of Pharmacology, Polish Academy of Sciences</s1><s3>POL</s3><sZ>2 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Department of Experimental Endocrinology, Institute of Pharmacology, Polish Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Mihaylova, Ivana" sort="Mihaylova, Ivana" uniqKey="Mihaylova I" first="Ivana" last="Mihaylova">Ivana Mihaylova</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Foundation of Biological Psychiatry</s1><s2>Sofia</s2><s3>BGR</s3><sZ>3 aut.</sZ></inist:fA14><country>Bulgarie</country><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author><author><name sortKey="Geffard, Michel" sort="Geffard, Michel" uniqKey="Geffard M" first="Michel" last="Geffard">Michel Geffard</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Association Institute for Research & Development in Human Pathology and Therapy</s1><s2>Talence</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Aquitaine-Limousin-Poitou-Charentes</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement><settlement type="city" wicri:auto="agglo">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Galecki, Piotr" sort="Galecki, Piotr" uniqKey="Galecki P" first="Piotr" last="Galecki">Piotr Galecki</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Adult Psychiatry, University of Lodz</s1><s2>Lodz</s2><s3>POL</s3><sZ>5 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Lodz</wicri:noRegion></affiliation></author><author><name sortKey="Leunis, Jean Clude" sort="Leunis, Jean Clude" uniqKey="Leunis J" first="Jean-Clude" last="Leunis">Jean-Clude Leunis</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Laboratoire Ategis</s1><s2>Wavre</s2><s3>BEL</s3><sZ>6 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Laboratoire Ategis</wicri:noRegion></affiliation></author><author><name sortKey="Berk, Michael" sort="Berk, Michael" uniqKey="Berk M" first="Michael" last="Berk">Michael Berk</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Deakin University</s1><s2>Geelong</s2><s3>AUS</s3><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Deakin University</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0218171</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0218171 INIST</idno><idno type="RBID">Pascal:13-0218171</idno><idno type="wicri:Area/PascalFrancis/Corpus">000A05</idno><idno type="stanalyst">FRANCIS 13-0218171 INIST</idno><idno type="wicri:Area/PascalFrancis/Corpus">000E18</idno><idno type="wicri:Area/PascalFrancis/Curation">005471</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000876</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000876</idno><idno type="wicri:doubleKey">0165-0327:2013:Maes M:increased:autoimmune:responses</idno><idno type="wicri:Area/Main/Merge">005050</idno><idno type="wicri:Area/Main/Curation">004E80</idno><idno type="wicri:Area/Main/Exploration">004E80</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression</title><author><name sortKey="Maes, Michael" sort="Maes, Michael" uniqKey="Maes M" first="Michael" last="Maes">Michael Maes</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Maes Clinics @ TRIA</s1><s2>Bangkok</s2><s3>THA</s3><sZ>1 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>Maes Clinics @ TRIA</wicri:noRegion></affiliation></author><author><name sortKey="Kubera, Marta" sort="Kubera, Marta" uniqKey="Kubera M" first="Marta" last="Kubera">Marta Kubera</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Experimental Endocrinology, Institute of Pharmacology, Polish Academy of Sciences</s1><s3>POL</s3><sZ>2 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Department of Experimental Endocrinology, Institute of Pharmacology, Polish Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Mihaylova, Ivana" sort="Mihaylova, Ivana" uniqKey="Mihaylova I" first="Ivana" last="Mihaylova">Ivana Mihaylova</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Foundation of Biological Psychiatry</s1><s2>Sofia</s2><s3>BGR</s3><sZ>3 aut.</sZ></inist:fA14><country>Bulgarie</country><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author><author><name sortKey="Geffard, Michel" sort="Geffard, Michel" uniqKey="Geffard M" first="Michel" last="Geffard">Michel Geffard</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Association Institute for Research & Development in Human Pathology and Therapy</s1><s2>Talence</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Aquitaine-Limousin-Poitou-Charentes</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement><settlement type="city" wicri:auto="agglo">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Galecki, Piotr" sort="Galecki, Piotr" uniqKey="Galecki P" first="Piotr" last="Galecki">Piotr Galecki</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Adult Psychiatry, University of Lodz</s1><s2>Lodz</s2><s3>POL</s3><sZ>5 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Lodz</wicri:noRegion></affiliation></author><author><name sortKey="Leunis, Jean Clude" sort="Leunis, Jean Clude" uniqKey="Leunis J" first="Jean-Clude" last="Leunis">Jean-Clude Leunis</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Laboratoire Ategis</s1><s2>Wavre</s2><s3>BEL</s3><sZ>6 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Laboratoire Ategis</wicri:noRegion></affiliation></author><author><name sortKey="Berk, Michael" sort="Berk, Michael" uniqKey="Berk M" first="Michael" last="Berk">Michael Berk</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Deakin University</s1><s2>Geelong</s2><s3>AUS</s3><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Deakin University</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of affective disorders</title><title level="j" type="abbreviated">J. affect. disord.</title><idno type="ISSN">0165-0327</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of affective disorders</title><title level="j" type="abbreviated">J. affect. disord.</title><idno type="ISSN">0165-0327</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigenic determinant</term><term>Autoimmunity</term><term>Chronic</term><term>Chronic fatigue syndrome</term><term>Cytokine</term><term>Depression</term><term>Inflammation</term><term>Oxidative stress</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Autoimmunité</term><term>Déterminant antigénique</term><term>Etat dépressif</term><term>Chronique</term><term>Stress oxydatif</term><term>Inflammation</term><term>Cytokine</term><term>Syndrome de fatigue chronique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: There is evidence that major depression is characterized by oxidative and nitrosative stress (O&NS). The aim of this study is to examine IgM-mediated autoimmune responses against a variety of modified neo-epitopes formed by O&NS damage to self-epitopes in chronic depression. Methods: Serum IgM antibodies directed against conjugated oleic and azelaic acid, malondialdehyde (MDA), phosphatidyl inositol (Pi), and conjugated nitric-oxide (NO) adducts, i.e., NO-tryptophan, NO-tyrosine, NO-arginine, and NO-cysteinyl, were determined in 33 healthy controls and 74 depressed patients subdivided into 28 patients with chronic (duration > 2 year) and 46 without chronic depression. Results: Serum IgM levels against all neoepitopes were significantly higher in depressed patients than in healthy controls. Moreover, the IgM levels were significantly higher, except Pi, in chronically depressed patients than in non-chronically depressed patients. Conclusions: Depression is characterized by IgM-related autoimmune responses directed against neo-epitopes that are normally hidden from the immune system but that became immunogenic secondary to damage by O&NS. The results show that the generation of neoantigenic determinants that lead to (auto)immune responses is strongly associated with chronic depression. Discussion: The damage caused by O&NS to auto-epitopes and the consequent formation of O&NS modified neoantigenic determinants may increase the risk to develop depression and in particular chronic depression through transition to autoimmune reactions. This has implications for understanding the immuno-inlfammatory and oxidative-autoimmune pathways that lead to chronic depression and neuroprogression in that illness.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Bulgarie</li><li>France</li><li>Pologne</li><li>Thaïlande</li></country><region><li>Aquitaine</li><li>Aquitaine-Limousin-Poitou-Charentes</li><li>Sofia-ville (oblast)</li></region><settlement><li>Bordeaux</li><li>Sofia</li><li>Talence</li></settlement></list><tree><country name="Thaïlande"><noRegion><name sortKey="Maes, Michael" sort="Maes, Michael" uniqKey="Maes M" first="Michael" last="Maes">Michael Maes</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Kubera, Marta" sort="Kubera, Marta" uniqKey="Kubera M" first="Marta" last="Kubera">Marta Kubera</name></noRegion><name sortKey="Galecki, Piotr" sort="Galecki, Piotr" uniqKey="Galecki P" first="Piotr" last="Galecki">Piotr Galecki</name></country><country name="Bulgarie"><region name="Sofia-ville (oblast)"><name sortKey="Mihaylova, Ivana" sort="Mihaylova, Ivana" uniqKey="Mihaylova I" first="Ivana" last="Mihaylova">Ivana Mihaylova</name></region></country><country name="France"><region name="Aquitaine-Limousin-Poitou-Charentes"><name sortKey="Geffard, Michel" sort="Geffard, Michel" uniqKey="Geffard M" first="Michel" last="Geffard">Michel Geffard</name></region></country><country name="Belgique"><noRegion><name sortKey="Leunis, Jean Clude" sort="Leunis, Jean Clude" uniqKey="Leunis J" first="Jean-Clude" last="Leunis">Jean-Clude Leunis</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Berk, Michael" sort="Berk, Michael" uniqKey="Berk M" first="Michael" last="Berk">Michael Berk</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004E80 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004E80 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:13-0218171
|texte= Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression
}}
| This area was generated with Dilib version V0.6.33. |  |